0. OVERVIEW
Our mission is to address healthcare unmet needs through the development of new technological concepts and real-world implementations. We are an interdisciplinary team where experts in experimental optics, fluidics, chemistry/materials, information science, and life science/medicine work together to advance invention-driven innovation and scientific discovery.
1a. Tech Dev: Cytometry and microscopy that learns from biology (actively recruiting!)
Data-driven high-content flow cytometry and sorters: Combining optical, fluidic, material, and information technologies, we are developing Learning Cytometers, where AI learns from biological data for analysis, for discoveries. (Actively recruiting postdocs with optics/engineering background)
Label-free bacterial spectrometry (coming soon)
Deep learning-based ultra-rapid nanometry. Nat XX 202X
Temporal flow cytometers (coming soon)
Ghost Cytometry: an image-free approach that enabled the world’s first “imaging“ cell sorter, driven by AI learned from biology. Science 2018, eLife 2021, Cell Rep Methods 2024, Stem Cell Rep 2024, Cells 2024, and so on.
3D-imaging Flow Cytometer: the world’s fastest 3D iFCMs. Small Science 2022, Biomed Opt Exp 2022, Small Methods 2023
Various new analysis techniques and sorters are under development
Microscopy-based live-omics and phenotypic screening technology (new! Actively recruiting postdocs!) Nat Photon 2024, Sci Rep 2014, Small Science 2022
Data analysis platform for developing inferring methods and digital-twin simulator
1a. Tech Dev: networked Pooled system
Networked biophotonics: using unique synthetic multimodal barcoding technologies that can trace a massive number of microcompartments of droplets and hydrogel capsules over time and different instrument for studying single-cells, cell-cell interaction, spheroids/organoids, and material synthesis. Adv Opt Mat 2023, Chem Eur J 2023.
Droplet and hydrogel modules: we routinely use and customize standardized techniques such as droplet generation, fusion, sorting, and various hydrogel structure creations, according to our needs. Sometimes develops our own.
2. biomedical, pharmaceutical and environmental study (actively recruiting postdocs who is motivated to work on technology development of A2 and its applications)
Using our high-speed and multimodal measurement platforms, we are addressing previously intractable issues in fields of
Hematology/oncology, immunology, infection, aging
Stem cell research, reproduction medicine
Novel diagnostics technologies
Stem cell research (actively seeking for postdoc)
Microbiology (actively seeking for postdoc)
EVs Anal Chem 2019, Nat Comm 2024.
The biological targets addressed are cells, bacteria, mall particles, their interactions, and XX-oids. These research is driven by biologists in Otalab or with collaborators.
Real-world implementation
Other technologies are in preparation for new start-ups.
Joint research and development with multiple companies is underway.
In cooperation with TECAN Ltd, we automate research and create the next generation of automation technologies.