We are actively recruiting postdocs with optics/engineering backgrounds or with microbiology backgrounds.
We are looking for graduate student with any background, who are highly motivated to develop innovative biotechnology.
0. OVERVIEW
Our mission is to address healthcare unmet needs through the development of new technological concepts and real-world implementations. We are an interdisciplinary team where experts in experimental optics, fluidics, chemistry/materials, information science, and life science/medicine work together to advance invention-driven innovation and scientific discovery.
1A. Tech Dev: Cytometry and microscopy for biology data-centric AI (actively recruiting!)
Learning Cytometers: we develop a series of AI-driven high-throughput and high-content flow cytometry (FCM) and sorters, aiming to fundamentally reverse the concept of human hypothesis-based conventional FCMs and free the value of optical signals from cells and EVs. Beyond developing measurement technologies with faster speed, higher resolution, higher sensitivity, and so on (yes, this is important so we keep creating them), we aim to maximize the power of label-free measurement free from human-limit.
We reported the world’s first AI-driven “imaging“ cell sorter, enabled by image production-free Ghost Cytometry. Science 2018, eLife 2021, Cell Rep Methods 2024, Stem Cell Rep 2024, Cells 2024, and so on.
We reported the world’s fastest (we still believe this is still true) 3D imaging flow cytometer with the aim to combine 1B technology. Small Science 2022, Biomed Opt Exp 2022, Small Methods 2023 Cells 2024.
We have reported the world’s fastest, Deep learning-based ultra-rapid EV analyzer Nat Comm 2025
We are reporting Temporally resolved flow cytometer (coming soon), Label-free bacterial spectrometry (coming soon)
New pooled analysis and sorting techniques are under development (new! Actively recruiting postdocs!)
We also develop microscopy-based live-omics and phenotypic screening technology (new! Actively recruiting postdocs!) Nat Photon 2024, Sci Rep 2014, Small Science 2022
Data analysis platform for developing inferring methods and digital-twin simulator
1B. Tech Dev: Networked Pooled Measurement system (actively recruiting!)
We have developed unique synthetic multimodal barcoding technologies for tracing a massive number of microcompartments of droplets and hydrogel capsules over time and different instrument for studying single-cells, cell-cell interaction, spheroids/organoids, and material synthesis. Adv Opt Mat 2023, Chem Eur J 2023.
Droplet and hydrogel modules: we routinely use and customize standardized techniques such as droplet generation, fusion, sorting, and various hydrogel structure creations, according to our needs. Sometimes develops our own.
2. biomedical, pharmaceutical and environmental study
Using our high-speed and multimodal measurement platforms, we are addressing previously intractable issues in fields of
Stem cell research, reproduction medicine, Stem Cell Rep 2024, Sci Rep 2024
Novel diagnostics technologies, Hematology/oncology, immunology, infection, aging
Microbiology (Actively recruiting! we are now enabling next generation cultuomics and multimodal bacterial analysis technologies)
The biological targets addressed are cells, bacteria, mall particles, their interactions, and XX-oids. These research is driven by biologists in Otalab or with collaborators.
Real-world implementation
Other technologies are in preparation for new start-ups.
Joint research and development with multiple companies is underway.
In cooperation with TECAN Ltd, we automate research and create the next generation of automation technologies.